Antigens FliD and CagA
A strong duo to detect H. pylori specific antibodies
FliD Antigen
(flagellar filament capping protein or flagellar hook-associated protein) is an essential element in the assembly of H. pylori´s flagella. It is an efficient, highly sensitive and specific marker, present in all H. pylori strains worldwide.
ImevaX holds the patent on the detection of FliD-specific antibodies.
CagA Antigen
(cytotoxin-associated antigen A) is one of the best studied and most important virulence factors. Subjects infected with H. pylori strains expressing CagA have a significant higher risk to develop complications, including gastric cancer, compared to H. pylori infections alone.
Principle of the Test
Pylori DuoTect® contains colored particles conjugated with the specific H. pylori antigens FliD and CagA.
When antibodies specific to FliD and/or CagA are present in the specimen, colored lines will appear in the antigen test (FliD: blue, CagA: red). Even a faint FliD and/or CagA line indicates a positive result.
If antibodies to these antigens are not present or are present below the detectable level, these lines will not develop.
Important: The red control line (C) must always appear regardless of the presence of antibodies to the H. pylori antigens. If this line does not appear, the test is invalid.
Even a faint control line (C) indicates that the test was performed properly.